THERAPEUTIC ACTIVITY OF DIFFERENT EXTRACTS OF BAUHINIA RACEMOSA LAM BARK ON CYSTEAMINE INDUCED ULCERS
Dr. C. Girish*, A. Neelima and D. Haritha Goud
ABSTRACT
An experiment was conducted to study the antiulcer effect of the dried bark powder of the plant Bauhinia racemosa in wistar albino rats. Cysteamine induced duodenal ulcer in the rat is widely used as a model of peptic ulcer disease. 36 wistar rats of either sex weighing between 180 -200gm were selected and divided into six groups, each comprising of 6 rats. 6 groups of rats were given with 0.5% CMC solution, 50 mg/kg of Ranitidine, 200 mg/kg of aqueous extract of Bauhinia racemosa, 400mg/kg of aqueous extract of Bauhinia racemosa (AEBR), 200 mg/kg of methanolic extract of Bauhinia racemosa and 400mg/kg of methanolic extract of Bauhinia racemosa (MEBR) respectively. After one hour all the groups were administered with cysteamine at a dose of 400 mg/kg body weight orally. After 24 hrs, note down the number of ulcers, ulcer score, percent incidence, ulcer index and healing index were recorded. From the results obtained it was concluded that the methanolic extract at a dose of 400mg/kg shows antiulcer activity.
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