Abstract

Mufeeda P.1, Nishad K. M.*, Sirajudheen M. K. and Shiji Kumar P. S.

ABSTRACT

Promising drugs are often discontinued during development because they cannot be suitably delivered to target cells, tissues and organs. The new generation therapy for various disorders needs a delivery system that target drug to specified cell types and host tissues. Virosomal technology represents a novel sophisticated delivery system to meet these challenges .Virosomes are reconstituted viral envelops that can fill in as vaccines or it can be utilized as vehicles for conveying peptide, nucleic acids and various medications like antitoxic ,anticancer agents and steroids. This safely modified viral envelop mainly consist of a phospholipid membrane and surface glycoprotein. It is derived from several virus envelops .Influenza virosome and sendai virosomes are most common. Their surface can be suitably modified to facilitate targeted drug delivery. How ever their pharmacokinetics clinical effect, bioavailability, stability etc. should be thoroughly studied to ensure long term reliability as safe, effective and affordable means of drug delivery. Thus drug delivery by using biomimetic novel drug delivery systems such as virosomes is a motivating research and development field. This review focus on various features of virosomes such as structure, advantages, disadvantages, formulation, application, kinetics etc