Abstract

Mohamed Fayis P.*, Dr. Lita Susan Thomas, Dr. Shijikumar P. S., Dr. Sirajudheen M. K. and Sherin A.

ABSTRACT

The aim of the review is to study the interaction between drugs and grape fruit juice. Grape fruit is a nutrition fruit. Many patient are concerned about the potential for drugs interaction with grape fruit juice. Grape fruit juice interact with many of the drugs produce severe problems. Grape fruit or grape fruit juice can alter enzyme in the body and effect how drugs are changed in the body before eliminated. Grape fruit juice decrease the activity of the cytochrome P450 3A4 enzyme that are responsible for taking down many drugs and toxins. It contains compound known as Furano coumarin that block CYP3A4 enzymes (CYP3A4 enzyme inhibition) which in turn affect s the metabolism of the drugs by this enzyme. Blood levels of the drug may rise, resulting in a risk for new or worsened side effects. The literature shows that one whole fruit or 200 milliliters of grape fruit juice can block the CYP3A4 enzyme and leads to drug toxicity metabolized by this enzyme. The review is done to analyze the alteration in clinical significance, class of drugs and the pharmacokinetic properties of drugs due to the interaction with the grape fruit juice. Therefore it is highly importa nt to know the effect of grape fruit juice on the pharmacokinetic properties of the drugs involved. The same information can be shared and highlight it importance while prescribing the drugs among the healthcare professionals specially the prescriber and t he public health promoting safe effective and rational use of drugs in the society.