Abstract

Manasi Nikam*

ABSTRACT

The objective of the present study is to formulate and evaluate raft forming chewable tablets of Famotidine for the treatment of gastroesophageal reflux diseases. The purpose of this research work was to formulate raft?forming tablets of Famotidine using a raft?forming agent along with an antacid? and gas?generating agent. Tablets were prepared by direct compression and evaluated for raft strength, acid neutralization capacity, weight variation, % drug content, thickness, hardness, friability and in vitro drug release.A 32 full?factorial design was used in the present study for optimisation. Tablets containing sodium alginate were having maximum raft strength as compared with other raft?forming agents. Acid neutralisation capacity and in- vitro drug release of all factorial batches were found to be satisfactory. The F9 batch was optimised based on maximum raft strength and good acid neutralisation capacity. Drug–excipient compatibility study showed no interaction between the drug and excipients. It was concluded that raft?forming tablets prepared using an optimum amount of sodium alginate and sodium bicarbonate could be an efficient dosage form in the treatment of gastro esophageal reflux disease.