Abstract

Fadi Ibrahim*

ABSTRACT

In this article, the antiviral activity of seven different carbon quantum dots (CQDs) with Azaphthalocyanin (Az-Pcs) for the treatment of human coronavirus infections was investigated. Az-Pcs used to adsorb UV light and concentrate it to CQDs to avoid destruction of tissue and cells by high energy. The first generation Az- Pcs-CQDs antiviral with nanostructures showed a concentration-dependent virus inactivation with an expected estimated EC50 of 50±8 ? gmL-1. The underlying mechanism of action of these Az-Pcs-CQDs could be due to interaction of the functional groups of the CQDs with COVID-19 entry receptors; surprisingly, an equally large inhibition activity was observed at the viral replication step. Az-Pcs with boronic acid derivatives have been proposed as low toxicity agents for inhibiting the entry various viruses. The underlying mechanism of action of these CQDs was revealed to be the CQDs interaction with the COVID-19 S-protein. The antiviral activity of Az-Pcs-CQDs with different Zn nano-size need to be evaluated on Huh-7 cell monolayers infected with COVID-19.