International Journal Of Modern
Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Science & Pharmacy Professional

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2319-5878
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Abstract

FORMULATION AND IN VITRO EVALUATION OF ORAL DISPERSIBLE TABLET OF DICYLOMINE HCL

Shivendra Agarwal*, Girendra Kumar Gautam, Neetu Rajpoot and Jagpal Singh

ABSTRACT

Dicyclomine HCL is an antispasmodic drug which is widely used in treatment of smooth muscle spasm of the gastrointestinal tract but it undergoes to first pass Metabolism. So that to develop Fast dissolving tablet of Dicyclomine HCL to avoid first pass metabolism and increase bioavailability. This offers a new range of product having desired characteristics and intended benefits. In this research, orally dispersible tablets of Dicyclomine HCL were prepared using direct compression method. Tablets produced by direct compression method contain Lactose as diluent, Crosscarmellose sodium, crosspovidone and husk as a superdisintegrant and aspartame as a sweetener. The dissolution study was performed on PBS 6.8 (salivary pH) and the In-vitro release was found 98.51% without leaving residue for F3 Batch.

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