Abstract

Navneet Kumar Verma*, Asheesh Kumar Singh, Prem Chand Mall, Vikas Yadav, Rupali Jaiswal

ABSTRACT

The development of this buccal and fast acting highly efficacious diuretic was a breakthrough. Its maximal natriuretic effect is way greater than that of other classes. The diuretic response goes on increasing with increasing dose: upto 10 L of urine could even be produced during each day . it's active even in patients with relatively severe renal failure . The onset of action is prompt (i.v. 2-5 min., i.m. 10-20 min., oral 20-40 min.) and duration short (3-6 hours) the main site of action is that the thick Asc LH (site II) where Furosemide inhibits Na+- K+-2Cl cotransport. A rare component of action on PT has also been indicated. it's secreted in PT by organic anion transport and reaches Asc LH where it acts from luminal side of the membrane. It abolishes the corticomedullary osmotic gradient and blocks positive also as negative free water clearance. K+ excretion is increased mainly because of high Na+ load reaching DT. However, at equinatriuretic doses, K+ loss may be a smaller amount than that with thiazides. Identification test was done by estimation of drug, infra-red spectroscopy, FTIR, UV-Spectroscopy, freezing point determination etc.