Abstract

Dr. Yadav Shalini M.D, Prof. Saxena Chandra Prakash M.D. PhD., Dr. Garg Richa*, M.D., Dr. Sachdev Kamal, M.D., Dr. Dharmendra, M.D, PhD., Dr. Gupta Deepika, M.D.

ABSTRACT

Aim: To evaluate the effectiveness of Pathyadi guggulu and Rasnadi gutika in cases of Gradhrasi (sciatic syndrome). Introduction: Gridhrasi i.e Sciatic syndrome is caused by pinching of sciatic nerve (nerve root is ventral rami of 4,5 lumbar and 1,2,3 sacral spinal nerve) which causing sharp shooting pain in the back of the leg running from the buttocks down the back of thigh into calf and foot. Settings and Design: For the present clinical study 68 Patients having Ruk (Pain which radiate to sphik, kati, uru, janu, jangha & pada successively), Sakthi utkshepa nigrahyad (restricted upward lifting of the affected lower limb), Stambha (Stiffness), Toda (Pricking sensation), Spandan (Tingling sensation), Tandra (Drowsiness), Gaurav (Heaviness) and Arochak (Anorexia) with Positive SLR TEST were registered. Materials and method: All patients were divided in two groups 34 patients in each. In Group A Pathyadi Guggulu were given orally 2 vati (500 mg each) 3 times daily after meal with Luke warm water for 60 days and in Group B Rasnadi gutika were given orally 2 vati (500 mg each) 3 times daily after meal with Luke warm water for 60 days. Type of study: Phase 2 rational, Randomized (Sequential) parallel group study. Statistical analysis used: p value, paired„t? test, unpaired „t? test, etc. Results: The trial drugs shows a significant results in terms of relieved & improvement in clinical parameters, out of 42 patients 64.28% were relieved, 28.57% patients were improved, 7.14% had no response, and there was no case of worsened had been reported. Conclusion: Trial drugs were well accepted and tolerated with good positive response and no any side effect has been observed.