EVALUATION OF IN VITRO ANTI CANCER ACTIVITY OF PLANTS FROM SIMAROUBACEAE FAMILY AGAINST HUMAN ORAL CANCER CELL LINE SCC-40
Dr. Aruna Rai* and Deepa Dahar
ABSTRACT
Cancer is one of the most deadly type of disease, encompasses a broad group of syndrome involving unregulated cell population expansion and sustained focus on development of novel anticancer agents from medicinal plants. A number of plant derived compounds play important roles in treatment of cancer. India has the highest number of cases of oral cancer in the world and this is increasing. Because the aetiology of oral cancer is predominantly tobacco related, the immense public health challenge can be meliorated through habit intervention. Plants from simaroubaceae family has been the subject of many studies regarding its chemical constitution and numerous compounds have been isolated for the treatment of many diseases. Quassinoids can be considered a taxonomic markers of the simaroubaceae family. The leaf, stem and stem bark extracts of Ailanthus excelsa, Quassia amara and Simarouba glauca were used for anticancer potential using sulforhodamine B (SRB) cytotoxicity assay against human oral cancer cell line (SCC-40). Adriamycin was used as the standard to compare the results. The median growth inhibition (GI 50) concentration for extracts of Ailanthus stem and Bark, Simarouba leaf and Bark was
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