Abstract

Ruchi Sharma* and Mangala Jadhav

ABSTRACT

Liver disease is a major health problem worldwide, and it makes it necessary to develop new drug or formulation that help counteract or prevent these liver diseases. Liver plays a main role in the metabolism and excretion. Due to this reason, liver is exposed more to toxicity. In addition to it, there is still lack of some reliable hepatoprotective drug, which arose the scope for finding new drugs. There has been tremendous work done on herbal and ayurvedic formulation in invitro and invivo models to evaluate their hepatoprotective activity. In this study all the work done on 287 preclinical studies on hepatoprotective activity are review and were compiled. The drugs or formulation that show hepatoprotective potentional in preclinical studies are the source of lead for researchers/medicals in treating the patients with liver disease and also for evaluating their safety and efficacy in the human trials.