Abstract

P.S.S. Prasanna Kumar*, A. Ravi Kumar, Srinivas Nandyala, B Devaki Devi, T. Anjali, Ch. Srividya, Ch. Divya, T. Pujitha, A. Evanjelin, N. Ramya Krishnaveni and Y. Sireesha

ABSTRACT

Aceclofenac is a Non-steroidal anti-inflammatory drug (NSAID) with marked anti-inflammatory and analgesic properties. The aim of the present work is to formulate a tablet which disintegrate and dissolve rapidly and give its rapid onset of action. The present study was to formulate and in-vitro evaluation of fast disintegrating tablets of Aceclofenac by using Natural polymer such as Pithecellobium dulce seed gum and Guar gum by direct compression technique using 3 different concentrations of 2%W/W, 4%W/W & 6%W/W. Each formulation was evaluate for various pre and post compression parameters such as Flow property, Bulk density, Tapped density, Weight variation, Hardness, Friability, Wetting time, Disintegration time, Assay, in-vitro dissolution. Among the 06 formulations, “F3” formulation Aceclofenac with 6%w/w of Pithecellobium dulce seed gum showed excellent disintegration time and best dissolution rate studies. In-Vitro dissolution studies showed (99.96%) release of drug within 20 minutes It was concluded that the fast disintegrating tablets are prepared by Natural polymer Pithecellobium dulce seed gum and Guar gum acts as a Fast disintegrant and the Pithecellobium dulce seed gum showed excellent disintegration time and enhance the dissolution rate compared to Guar gum.