Abstract

T. Anjali*, N. Srinivas, P. SS. Prasanna Kumar, P. Brahma Teja, D. Praneetha, P. DS Anjali, K. Vijaya, G. Swarajya Rao and S. Siva Saradhi

ABSTRACT

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties. The aim of the present work is to design and formulate a tablet which disintegrate and dissolve rapidly, give its rapid onset of action. The present study was to Formulate and evaluation of fast disintegrating tablet of Aceclofenac by using Natural polymer extracted from “Phyllophora Ribis” mushroom by direct compression technique in 05 different concentrations of 2%W/W, 4%W/W, 6%W/W, 8%W/W & 12%W/W. Each formulation was evaluate for various pre and post compression parameters such as Flow property, Bulk density, Tapped density, Weight variation, Hardness, Friability, Wetting time, Disintegration time, Assay, in- vitro dissolution. Among the 05 formulations, F5 formulation Aceclofenac with 12%w/w of mushroom extract powder showed the best dissolution rate studies. In-Vitro dissolution studies showed (99.98%) release of drug within 25 minutes and the mechanism of drug release from the tablets was followed to be first order kinetics. It was concluded that the fast disintegrating tablets are prepared by Natural polymer extracted from P.Ribis mushroom acts as a Fast disintegrant and the mushroom polymer powder showed excellent disintegration time.