Abstract

Shalaka Vijay Borse* and Dr. Vaibhav Kumar A. Jagtap

ABSTRACT

New drug delivery system for the oral delivery of drug, was developed based on the technology of the transdermal patch. It consists of a very thin oral strip which releases the active ingredient immediately after uptake into the oral cavity. The technique involved in the preparation of mouth dissolving film was solvent casting method in which aqueous solution I (Pantaprazole Sodium, Sodium Starch Glycolate, Ascorbic acid, Vanilla flavour and Saccharin) and aqueous solution II (HPMC E15 and Glycerine) was prepared in specific proportion in distilled water. Both solution I & II were mixed & stir for 1 hour & kept for 1 hour to remove all air bubbles. Then the mixture solution was poured into petridish & it was dried in oven at 40-50 0C for 7- 8 hours then film was removed from petridish and cut according to Size (square film: 2cm length, 2cm width). Pantaprazole is a highly potent proton pump inhibitor, chemically a weak base, it concentrates under the acidic conditions of parietal cell secretory canaliculi where it is converted to a cationic cyclic sulfonamide by rearrangement. This activated molecule binds to two site of hydrogen/potassium ATPase (proton pump) in the gastric parietal cells, inactivating the system, which in turn blocks the final step of secretion of hydrochloric acid by these cells, producing a long lasting effect.