Abstract

Bharti Mittu* and Neha

ABSTRACT

The innate immune system is the most primitive and evolutionary conserved arm of the immune system. It triggers a sequence of events leading to release of the proinflammatory cytokines and activation of the acquired immune system (T and B lymphocytes). Once T and B lymphocytes activated, these lymphocytes generate microbial antigen-specific cell-mediated and antibody-mediated immunity. A delicate balance is maintained by a complex interplay of local humoral, cell mediated and innate immunity in female reproductive system (Summers et al., 2010). Innate immune system can recognize multiple microbes and components of their cell walls. The potential pathogens can be eliminated by multiple mechanisms, which include antimicrobial factors secreted by local epithelial cells, ingestion by resident phagocytes and activation of an inflammatory response (Janeway et al., 2005).