Abstract

Kirti Negi*, Dr. Kapil Kumar and Deepak Teotia

ABSTRACT

Pharmacosomes are colloidal dispersion of drugs covalently bound to lipids and may exist as ultrafine vascular, micellar or hexagonal aggregates, depending on the chemical structure of drug-lipid complex. Pharmacosomes are the amphiphilic phospholipid complexes of drug bearing active hydrogen that bind to phospholipid. It is based on the principle that the drug binds covalently to a lipid where the resulting compound is the carrier and the active compound at the same time. The physicochemical properties depend on drug as well as the lipid. They are mainly prepared by hand-shaking and ether injection method. The Pharmacosomes were evaluated for different parameters such as size, NMR, surface morphology and invitro release rate. This review describes all aspect of Pharmacosomes including composition, method of preparation, method of characterization and their therapeutic application. Pharmacosomes have been prepared for various non steroidal anti-inflammatory drugs, proteins, cardiovascular and anti-neoplastic drugs.