Abstract

Dr. Mehnoor Farheeen*, Neha Jabeen, Syeda Qadar Unnisa and Zehra Fatima

ABSTRACT

The testimony presented hereby fortify the entrenched use of Apocynum venetum and Chrysanthemum balsamita to alleviate depression. Regardless of extensive use of Apocynum venetum and Chrysanthemum balsamita for treating assorted affictions there is no report/ knowledge of scientific appraisal in combination of Apocynum venetum and Chrysanthemum balsamita of its anti-depressant activity. Investigation performed shows that, when the extracts of Chrysanthemum balsamita and Apocynum venetum administered to an animal model (mice), had conspicuous effects on depression pertinent related behavioral parameter’s on vulnerability to TAIL SUSPENSION TEST &FST in mice. Extracts of A. venetum and C. balsamita in combination causes anti-depressant behavior comparable with the effects of imipramine. Further investigations should be focused on neurobiological MOA and potential synergy of Chrysanthemum balsamita and Apocynum venetum extracts in combination with phytoconstituent (s) and neurotransmitters responsible for observed central actions has to be confined and recognized.