Abstract

Dr. Mehnoor Farheen*, Syeda Khairunnisa Amreen, Zehra Fatima and Syeda Qadar Unnisa

ABSTRACT

The study was conducted which involves the investigation of protective action of liver by using tubers of juncus sabulatus and the leaves of cordia macleodii against isoniazid and rifamocin induced toxic rats models.the action was assayed using ethanolic extracts by using maceration technique. The extract were screened for standard phytochemical screening. The study was analysed by invitro and invivo methods by i.p administration and the mortality and toxic signs was observed for 24hrs.The study was carried out for 21days, and were administered with dose of 200mg/kg body weight and 400mg/kg bof dy weight both individually and in combination respectively against isoniazid and rifampicin toxicated rats. Silymarin was used as a refrence standard.The biochemical parameters ,ic50 value and histological resukts wre carried out. The reults shows the effects by decrement in the levels of GOT,ALP,MDA,alkaline phosphate and total bilirubin and increasing the levels of total protein,albumin,SOD and CAT. By this study it as found that the plants contain moderate effect of protective action which was supported by the histopathological reports.