AMELIORATION OF SYMPTOMS AND OXIDATIVE STRESS IN HOSPITALIZED CONVALESCENT POST SARS-COV-2 PATIENTS TREATED WITH RECTAL OZONETHERAPY AND NUTRITIONAL SUPPLEMENTATION
Lizette Gil-del-Valle*, Olga Elena López-Fernández, Joniel Arnoldo Sánchez- Márquez, Zullyt Zamora-Rodríguez, Ana Librada Carballo- Reyes, Lidia Asela Fernández-García, Mario Manuel Delgado-Guerr
ABSTRACT
Context: Inflammatory responses induced by SARS CoV-2 and also metabolic effects of drugs used could increase generation of endogenous reactive oxygen species which persist after viral recovering contributing to detrimental outcomes. Recommendations for therapeutic strategies are suggested in order to reestablish balance between oxidative damage and antioxidant system. Aims: Determining the effect of BIOPLA and rectal insufflation ozone therapy (RIO3T) intervention in Cubans SARS-CoV-2 convalescent patients. Materials and methods: Forty patients received 1-BIOPLA capsule (400 mg) daily or 2-BIOPLA capsule plus RIO3T daily during one month. The assessment of patients considers anthropometry, symptoms, chemical, haematological, and five plasma redox indexes. Twenty presumable healthy subjects were studied and considered as control group. For evaluating the effect of interventions all variables measured in final session were compared with the baseline values. Adverse reaction was checked during follow-up. Different statistical analyses were done. Results: Relatively to the control group, both groups of convalescent patients had significant differences in some redox, chemical and haematological indexes at baseline (p
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