Abstract

Shravan Kumar Dholi*, Syeda Tanveer Fathima, Ramakrishna Raparla

ABSTRACT

Traditional medication obtained from the medicated herbal plants are used by about maximum percentage of world population for different chronic disease condition. Diabetes (Hyperglycemia- high blood sugar level) is a very important metabolic disorder in different developed, developing countries including India. It providing to a very serious complications on health of human beings, especially in the rural and subrural areas. Capsicum is an annual herb that anti hyperglycemic activity. Other pharmacological properties such as anti inflammatory, antioxidant, anti microbial, antiviral, hypotensive, and hypercholesterolemia are also exhibited. However, the research so far on the hypoglycaemic effect of Capsicum could’t establish the optimum dose-level for experimental subjects. Hence, the research studies required to be subjected to pharmacodynamic and pharmacokinetic studies in order to determine effect of Capsicum herb on the hyperglucemic patients who are taking the therapy with synthetic drugs. This research work was to identify the influence of Capsicum on the pharmacokinetic and pharmacodynamic of Pioglitazone in rats. Results have proves the negative (decrease) effect of Capsicum on pharmacokinetics but positive (increase) effect on pharmacodynamics of Pioglitazone.