COMBINING HIPPOCRATEA AFRICANA ROOT BARK EXTRACT WITH ARTEMETHER-LUMEFANTRINE IMPROVES BIOCHEMICAL INDICES OF RENAL FUNCTION IN PLASMODIUM BEHGEI INFECTED MICE
Anthony Fidelis Uwah*, Henry Dan Akpan and Blessing Obinaju Effiong
ABSTRACT
Many patients have resorted to the use of herbal remedies, either alone or in combination with standard antimalarial drugs, to alleviate their symptoms due to parasitamia. Our study aimed at evaluating the effect of combining Artemether-Lumefantrine, an artemisinin-based combination therapy (ACT), with Hippocratea africana, a tropical medical plant, on some biochemical indices of renal function of Plasmodium berghei infected mice. Fifty albino mice weighing between 30 - 35g were divided into five groups of ten mice in each. Parasites were got from infected blood of a donor mice. The root extract was obtained using 80% ethanol. Calculated amount of ACT and crude root bark extract of H, africana were sustained in normal saline and administered orally to parasitized mice. A non-parasitized and parasitized untreated groups were administered only normal saline. Blood samples and serum were got using standard procedures. Serum electrolytes, creatinine, urea and blood pH were determined. The results showed a significant (P
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