Abstract

Shirish S. Pingale*, Popat S. Virkar, Rajendrashing G. Mahale and Verla Andrew Wirnkor

ABSTRACT

The aim of the present work is to evaluate the acute toxicity study of dry powder Coriandrum sativum Linn leaves. The leaves of this plant were collected from Rajgurunagar area of Pune district, Maharashtra, INDIA. The fresh leaves were dried in shade till constant weight for few days and grinded with high power electric mixer. The dry sample was kept in airtight plastic container and was used for toxicity study as per OECD guidelines by using white albino Wister Rats. The plant material was administered orally at dose of 2 to 10gm/Kg body weight of Swiss mice. The animals were observed continuously for the period of first 4 hours continuously for behavioral changes and then they were kept under observation for 14 days after single administration of powder in the form of aqueous slurry with the help of gavage. The mortality observations were recorded to find out the toxic effect of leaves of Coriandrum sativum Linn. From these results it is observed that Coriandrum sativum Linn leaves powder at higher doses of 10gm/kg body weight is found to be nontoxic in male as well as in female, as no any type of abnormal changes were reported in behavior, food and water intake of the administered animals. The Coriandrum sativum Linn leaves powder was found to be relatively safe when administered orally in Swiss mice. Lethality or adverse toxic signs were not at all observed during the experimental period for our sample.