Abstract

Pratik Kayasth, Smit Patel*, Kruti Bhatt, Krishna Kanoje, Vishal Chauhan, Dr. Jitendra Patel and Dr. Umesh Upadhyay

ABSTRACT

The purpose of this Project work is to prepare fast dissolving tablets of Domperidone by wet granulation. In the present study, Sodium Starch Glycolate, was taken as super disintegrant and starch paste as a binder for Preparation of fast dissolving Domperidone Tablet. Here the Domperidone (anti-emetic) is taken as the model drug for the study and wet granulation as a method for preparation of the Fast Dissolving Tablet. The disintegrant incorporated during the wet granulation process as extra granular incorporation. Here the concentration of Superdisintegrants and concentration of starch paste were taken as independent variables. The effect of Disintegration time and friability were investigated as dependent parameters. The optimized batch obtained from the study was compared with the marketed products.[1] Oral medication conveyance is the most prominent defeat. It is outstanding since quite a while for its generally utilized course of organization among all the failure that has been investigated for the precise conveyance of medication arranged different measurements from the pharmaceutical items. Dysphagia is a typical issue which needs to look in all times of gatherings in worry to strong dose shapes. The patient needs to improve consistency to take care of the problem of Dysphagia. The Rapidly dissolving tablets have risen as an option in contrast to regular oral medication use.[2]