International Journal Of Modern
Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Science & Pharmacy Professional

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2319-5878
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Abstract

IN VITRO ANTIMALARIAL ACTIVITY OF ANNONA RETICULATA FRUITS EXTRACTS BY SYBER GREEN I BASED FLUORESCENCE METHOD

Dr. Akhila S., Prof. Anu V.* and Sarath D.

ABSTRACT

The most serious form of malaria caused by Plasmodium falciparum continuous to be a major public health problem. As a result, this study aimed to assess the antimalarial potential of ethanol leaf extracts. The cytotoxicity study of crude drug extracts accessed against Vero cell line and their antimalarial activity investigated against Plasmodium falciparum 3D7 and KI strain. Syber Green I Based fluorescence In vitro antimalarial study was used to access the efficacy of Annona reticulata extract. The plant extracts had no cytotoxicity effect on the Vero cell line (CC50= 200µg/ml). This study showed moderate antimalarial activity of ethanolic extract with IC50 values of 3D7 and KI are 38.5 and 52 respectively. The present study indicates that Annona reticulate could be a good source of antimalarial agent.

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