Abstract

Kanupriya Choudhary*, Nimrata Seth and Naresh Singh Gill

ABSTRACT

The objective of the study is to prolong the gastric residence time, increase drug bioavailability and also to target the gastric ulcer for local drug action. A floating drug delivery system of famotidine was developed using hydroxy propyl methyl cellulose K4M, Xanthum gum, guar gum in various ratios. The tablets were prepared by wet granulation. The formulated tablets were evaluated for weight variation, hardness, buoyancy lag time. The prepared tablets exhibit satisfactory physical characteristics. All formulations showed good in vitro buoyancy. The results of the invitro release studies show that the formulation remain buoyant for more than 12 hrs. Finally, the tablet formulation was found to be economical and will overcome the draw backs associated with the drug during its absorption.