Abstract

N. P. Pranamya*, G. Indiradevi, M. Ali Hassan and Susannah Seth

ABSTRACT

The antimicrobial drugs occupy a unique niche in the history of medicine. Amino acid complexes are proving to be an efficient antimicrobial drug nowadays. The new Benzilic acid –tyrosine metal complexes were prepared on condensation of Benzilic acid and the amino acid, tyrosine and the synthesized compounds were authenticated by UV-Visible, Fourier Transformer-Infrared (FT-IR) and Gouy Method techniques, Elemental analysis, Molar conductance study. Tyrosine, a non-essential amino acid used widely as a precursor to neurotransmitters. Benzilic acid and its derivatives are of wide interest due to their diverse antimicrobial activities. The synthesized compounds were authenticated by UV-Visible, Fourier Transformer-Infrared (FT-IR) and Gouy Method techniques. The biological activity of the DT ligand and its complexes has been tested for antibacterial effects against Staphylococcus Aureus and Escherichia coli using well diffusion method. The antibacterial study revealed that compound S4 showed excellent activity against gram positive bacteria Staphylococcus Aureus. The S4 complex was found to be more potent than free ligand showing that on complexation the activity of the complexes were altered. [1] Certain metal ions possess effective antimicrobial activity; here the Cobalt complex is efficient to act against Staphylococcus Aureus.