Abstract

*Gnaneswari Regati and Giri Raja Sekhar Dornadula

ABSTRACT

Sjogren’s syndrome is a persistent autoimmune disorder discriminates the symptoms of xeropthalmia, xerostomia, tiredness, arthralgia, and inflammation of major salivary glands. These symptoms of SS are due to excessive lymphocytic infiltration.Women with Sjogren’s syndrome considerably greater than men; the gender dissimilarity tries between 9:1 to 19:1. SS is associated with genetic factors which may be triggered through some viruses and strain.SS can have effect on both central nervous system and peripheral nervous system. Pathophysiology of SS focus on part of epithelial tissue, cytokines, T-lymphocytes cell activating factor (BAFF) in the pathology and inaddition autoantibody secreted by B lymphocytes. Treatment goals of SS consists of palliative control of signs and symptoms, preventing complications and immunosuppressive agents which consist of medications such as cyclophosphamide, methorexate, mycophenolate and azathiaprine which suppress the immune system. Potential healing interventions encompass BAFF inhibitors and anti-CD20 and anti-C22 therapy. Here we portray a case of 45 years old women with clinical manifestations of dry eyes, dry mouth, swelling of the lips and burning micturition. Specific antigen tests, ocular examination and other laboratory tests were performed. She was identified as Sjogren’s syndrome and her signs and symptoms receded after treatment.