Abstract

Oraeluno J. N.*, Obasi J. C., Bamigbola E. A. and Joseph B. A.

ABSTRACT

The aim of this study is to evaluate the binding ability of Azanza garckeana pectin. For this purpose, pectin was obtained by precipitation with 96% ethanol. Three different batches of diclofenac sodium tablets were formulated using 5%w/w of Azanza garckeana (Ag) pectin in comparison to Tragacanth (Tr) and Acacia (Ac) at same concentration. Pre-compression and post-compression studies were performed for each formulation. The results obtained for pre and post-compression parameters were found within acceptable pharmacopoeial range. The results showed that at 5% w/w concentration, hardness test was in this order: Ag>Tr>Ac, all the tablets had friability of < 1%. Disintegration time test showed that increase in hardness value increased the disintegration time with Ag, Tr and Ac disintegrating in 16.00, 15.00 and 12.00 minutes respectively. This study concludes that Azanza garckeana at 5%w/w concentration gave better binding capacity than tragacanth and acacia, hence might be explored in future for introduction as a binder in the pharmaceutical industry.