International Journal Of Modern
Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Science & Pharmacy Professional

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2319-5878
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Abstract

FAMOTIDINE SOLID DISPERSION AND ADMINISTRATION BY ORAL ROUTE

Jagpal Singh*, Jonny Kumar and Anuj Kumar

ABSTRACT

Background: famotidine is a H2 Blockers drugs having a component of low aqueous solubility and less oral bioavailability. Its need to develop of solubility and dissolution rate obtained for good therapeutic effect. Materials and Methods: The objectives of famotidine current work to formulation of solid dispersion (SDs) by kneading method for aqueous solubility enhancement. The low solubility problems were eliminated by preparing the solid dispersion using the poloxamer 188 as hydrophilic carrier. Result and Conclusion: The Famotidine tablets of solid dispersion characterized by employing solubility, FTIR, friability test, disintegration test, wetting time in-vitro drug release. The high value of solubility of Famotidine (FAM) solid dispersion were prepared Successfully, enhance dissolution rate and bioavailability.

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