Abstract

Rohit Verma*, Chitra Gupta, Ali Mohd Ganie, Vaibhav Kumar, Sanjay Singh and P.K. Singh

ABSTRACT

Benzimidazole is a heterocyclic aromatic organic compound containing nitrogen. This bicyclic compound is formed by the fusion of benzene with imidazole ring. It is a vital Pharmacophore and privileged structure in medicinal chemistry which exhibits various therapeutic activities like antiulcer, antihypertensive, analgesic, antiviral, antifungal, anticancer and antihistaminic. The disease conditions targeted by these activities are discussed. The present article extensively covers various procedures of synthesis of 2- substituted benzimidazole and its analogs by utilizing different catalysts, solvent conditions, reactants and microwave irradiation with the aim to obtain an inexpensive, eco-friendly, less time-consuming procedure which ensures good yield and quick isolation of the pure product. Presence of benzimidazole nucleus in numerous categories of therapeutic agents such as antimicrobials, antivirals, antiparasites, anticancer, anti-inflammatory, antioxidants, proton pump inhibitors, antihypertensives, anticoagulants, immunomodulators, hormone modulators, CNS stimulants as well as depressants, lipid level modulators, antidiabetics, etc. has made it an indispensable anchor for development of new therapeutic agents. This review is summarized to know about the chemistry of benzimidazole and their derivatives of substituted benzimidazole along with their physical and chemical properties. We demonstrate the change in properties of benzimidazole with change in their structure, their isomers, uses and their pharmacological activity.