Abstract

Ravina N. Pounikar*, Dr. Mrs. Suparna S. Bakhale, Jayshree V. Motghare, Anuja Bhure, Madhav Korde

ABSTRACT

Poor solubility of drugs is a major challenge in the formulation development. Solid dispersion is introduced as a novel means for enhancement of solubility. Solid dispersion may be defined as a set of solid products comprising of at least two diverse components, usually hydrophilic matrix and hydrophobic drug. Depending on nature of carriers the immediate release solid dispersions and/or controlled release solid dispersions can be formulated. This matrix may be crystalline or amorphous in nature. As per biopharmaceutical classification system class II drugs are with low solubility and high permeability and are the promising candidates for improvement of solubility as well as bioavailability by means of solid dispersion. The carriers used previously were mostly synthetic one. Recent trend towards the use of natural carriers have replaced the use of synthetic carriers. This review is the overview of various synthetic, natural, semisynthetic, modified natural hydrophilic carriers used for formulation of solid dispersions. Since a solid dispersion is basically a drug–polymer two-component system, the drug– polymer interaction is the determining factor in its design and performance. In this review, we summarize our current understanding of solid dispersions both in the solid state and in dissolution, emphasizing the fundamental aspects of this important technology Practical aspects pertaining to preparation of solid dispersions, like the selection of carrier, drugs molecular arrangement in these preparations are discussed in this article. Proposed article highlights the various preparation techniques of solid dispersion, characterization, available recent technologies, marketed preparation, future prospective etc.