Abstract

*Tejaswini W. Fulzele, Swati K. Turkar, Dr. Mrs. Gauri R. Dixit, Dr. Mrs. Suparna S. Bakhle

ABSTRACT

In development of new product major constraints are poor aqueous solubility and low oral bioavailability. Crystallization emerge as potential technique for enhancement of solubility of poorly aqueous soluble drugs also helps to improve physicochemical with preserving the pharmacological properties of the API. Cocrystals are solids that are crystalline single-phase materials composed of two or more different molecular and/or ionic compounds generally in a stoichiometric ratio which are neither solvates/hydrates nor simple salts. It is multicomponent system in which one component is API and another is called coformer. Coformer selection is the main challenging step during cocrystal synthesis, so various screening methods for the selection of coformers was explained. This article also summarizes differences between cocrystals with salts, solvates and hydrates along with the implications and limitations of cocrystals. It also provides a brief review on different methods of cocrystal formation and characterization technique of cocrystals.