Abstract

Kavita S. Mundhe*

ABSTRACT

Many Schiff bases are medicinally important hence used to design medicinal compounds. Chelation with metal may increase the biological activity of the Schiff bases. Transition metal complexes of O-donor ligands possess antibacterial, antifungal and anti-inflammatory activity. Transition metal complexes of N-donor ligands (Schiff bases) showed anti-Candida activities. Copper complexes are important due to the variety in their coordination chemistry, technical applications, catalysis, spectroscopic properties, anion selectivity, and their biological significance. Taking into consideration the important applications of these compounds the study of dimedone derivatives and their copper complexes have been carried out. The copper complexes of 5, 5-dimethyl-3-(phenylimino) cyclohexanone (L1), 5, 5 -dimethyl-3-(o-phenylimino) cyclohexanone (L2), 5,5-dimethyl-3-(m-phenylimino) cyclohexanone (L3), 5,5-dimethyl-3-(p-phenylimino) cyclohexanone (L4) have been synthesized. The synthesized complexes are characterized by using magnetic measurements, thermogravimetric analysis and spectral techniques. These metal complexes have been evaluated for their antimicrobial and anthelmintic activity. It is observed that the Schiff bases coordinated to metal ions through amine nitrogen and oxygen of carbonyl group. The anti microbial study shows that the metal complexes show better activity against bacterial strain Staphylococcus aureus in comparison to the ligands. The copper complex shows significant anthelmintic activity.