International Journal Of Modern
Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Science & Pharmacy Professional

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2319-5878
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Abstract

FORMULATION AND EVALUATION OF MATRIX TABLETS OF LOSARTAN POTASSIUM

Vinod Babaleshwar*, Vinod Reddy, Vitthal Vijapure and Prashant Jorapur

ABSTRACT

The current study was designed to develop sustained release matrix tablets of losartan potassium used to treat hypertension. The sustained release matrix tablets were prepared by direct compression method using different polymer ratio with the drug, nine such formulations were prepared (F1 to F9). The polymers with hydrophilic (HPMC) and hydrophobic (Ethyl cellulose) nature as well as one natural polymer (Gaur Gum) were used. The drug compatibility with the excipients was evaluated. The compatibility showed by formulations was in compliance with the limits prescribed in pharmacopoeia. The formulation F7 showed remarkable pre-compression and post compression parameters when compared with other formulations as it had robust nature with optimum hardness, uniformity weight and friability. In-vitro dissolution study of F7 showed the sustained release of drug losartan potassium (96.26%) release at the end of 12th hrs. Increased polymer ratio showed decrease in release kinetics of drugs.

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