Abstract

Prajakta Ghatage*, Vijaya Govande, Omkar Gurav, Pooja Hupare, Sanyogita Harale, Sandip Bandgar and Sachin Patil

ABSTRACT

Niosomes acts as a novel drug delivery system, in which the formation of niosomes can take place by using non-ionic surfactants. The particle size of niosomes required must be in the range between 10nm to100nm which is mainly to avoid the fusion and its aggregation. There are many types of niosomes but their types and size mainly depend on the method used for its preparation. There are many factors affecting on the formation of niosomes such as nature of drug, type of surfactants used, cholesterol content and charge, resistance to osmotic stress and temperature of hydration. Various methods are used for separation of un-entrapped drug from final product such as dialysis, gel filtration and centrifugation. There are several routes used for its administration includes oral, parenteral, transdermal, ocular etc. The present article represents the preparation, characterization of niosomes and its effective applications in the drug delivery.