International Journal Of Modern
Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Science & Pharmacy Professional

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2319-5878
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Abstract

REVIEW ON FORMULATION AND EVALUATION OF VERAPAMIL BY USING SOLID DISPERSION TABLETS FOR SOLUBILITY ENHANCEMENT

Manisha K. Pimpalkar*, Swapnali S. Todkar, Akshada V. Deshmukh and S. V. Patil

ABSTRACT

The goal of the research was to use solid- dispersion via direct compression to increase the solubility and dissolving rate of the medication Verapamil. Solid dispersions were prepared by solvent evaporation technique using PEG 6000 and Urea as carriers. Verapamil solid dispersion was developed by, melt solvent method and to modify the release and enhance solubility of the drug. The used to determine the physical state of the disseminated verapamil in the polymer matrix. By using the direct compression method, verapamil solid dispersions (FT 12) were formed into tablets. Verapamil solid dispersion dissolving was considerably improved as compared to pure drug and physical mixture. The results of this investigation convincingly showed that using water soluble carriers in various solid dispersion processes enhanced the solubility of poorly water-soluble drugs.

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