SYNTHESIS, CHARACTERISATION, DOCKING STUDIES AND ANTIMICROBIAL EVALUATION OF ETHYL 3-(5-(2-OXIDO-2-(4-SUBSTITUTED PHENOXY) BENZO[D][1,3,2]DIOXAPHOS PHOL-5-YL)-1H-TETRAZOL-1-YL)THIOPHENE-2-CARBOXYLATES
Y. N. Spoorthy, P. Vijaya Kumar*, T. Sailaja Rani and L. K. Ravindranath
ABSTRACT
The reaction of ethyl 3-((3,4-dimethoxybenzylidene)amino) thiophene-2-carboxylate (5) reacts with phosphorus tri chloride followed by sodium azide in presence znic chloride, sodium acetae in tetrahydrofuran forms ethyl 3-(5-(3,4-dimethoxyphenyl)-1H–tetrazol-1-yl)thiophene-2-carboxylate (6) which on hydrolysis affords the ethyl 3-(5-(3,4-dihydroxyphenyl)-1H–tetrazol-1-yl)thiophene-2-carboxylate (7). A new series of ethyl3-(5-(2-oxido-2-(4-substituted phenoxy)benzo[d][1,3,2]dioxaphosphol-5-yl)-1H-tetrazol-1-yl)thiophene-2-carboxylates (9a-g) were synthesized from ethyl 3-(5-(3,4-dihydroxyphenyl)-1H–tetrazol-1-yl)thiophene-2-carboxylate (7) by condensing with 4-substituted phenyl phosphoro dichloridates (8a-g). The structures of these analogues (9a-g) have been established by 1H NMR, IR, Mass spectral data and elemental analysis. This study describes the anti-microbial activity and docking studies of newly synthesized analogues (9a-g).
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