FORMULATION AND EVALUATION OF BUDESONIDE CONTROLLED RELEASE TABLETS BY USING NATURAL GUM
Dr. Sathya Surya Prasad CH*, G. Dakshayani, V. Manohar, I. Madhuri Priya, J. Dakshayani and S. Chandra Sekhar
ABSTRACT
The aim of present work was to develop 300mg control release budesonide tablets by using direct compression method. It is a potent glucocorticoid used for the treatment of ulcerative disease and wheezing and shortness of breath caused by asthma. In this work four formulations are selected for the design of budesonide controlled release formulations. In this formulations are prepared by using different concentrations gum karaya as a polymer and different ingredients are used as fillers to develop the formula. The granules and tablets are evaluated by FT-IR, DSC, pre-compression, post-compression parameters and In-vitro dissolution studies. Based on the dissolution studies F4 was selected as an optimized formula because of it gives best results in controlled by drug release manner and best fitted to order of kinetics.
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