Abstract

Jaya Bhati*, Amarjeet Singh and Giriraj T. Kulkarni

ABSTRACT

In current scenario, Herbal Formulations are being treatment of choice, as Allopathy drugs posing harmful side effects and additionally, microbes developing resistance to Allopathy drugs. Hence, the development of herbal formulation is going to be essential for enhancing the patient’s quality of life, safety and avoiding harmful side effects. In this study, we have explored anti-bacterial activity of ethanolic extract of Thymus vulgaris and Cinnamomum verum against Propionibacterium acnes.Thymus vulgaris and Cinnamomum verumwere macerated with aqueous-ethanolic solution to get extracts.The formulated proniosomal gel by using surfactants, lecithin, cholesterol with extracts. Formulations were evaluated for its physicochemical parameters and other parameters like TEM, DLS, in vitro study, optical microscopy. The efficacy of Thyme and Cinnamon was determined by evaluating zone of inhibition against standard Clindamycin.The formulated proniosomal gel was found effective against the acne and it was able to kill acne causing bacteria (P.acnes) and provide controlled release upto 24 hours.