Abstract

*Rakshith B. K., Kiran Kumar G. B., Madhu B. K. Jayatheertha S. Lokapur, Arpitha J. Lokapur

ABSTRACT

The aim of this work was to develop and evaluate a buccal films for oral delivery of Cephalexin. Method: Cephalexin-loaded buccal films were prepared by using mucoadhesive polymers like HPMC K4M and Chitosan, using a solvent casting method. The films were evaluated in terms of thickness, weight, folding endurance, drug content, drug release study, release kinetics studies, and short-term stability study. Results: The cumulative percentage release of Cephalexin from different mucoadhesive buccal films varied from 96.68±1.53 % to 99.89±1.21 % depending uponthe polymer plasticizer ratio and the type of plasticizers used. The order of in-vitro drug release data was found to be highest for formulation F11 [(containing Chitosan: tween80: PEG 400 (10%)]. The drug release kinetic showed Higuchi release kinetic and found to follow non-Fickian release mechanism. Stability results exhibited no significant change in drug content, and percentage drug release when stored at room temperature. Conclusion: It can be concluded that buccal films of Cephalexin could provide sustained buccal delivery for prolonged period.