Abstract

Azra Banu Gokak, Nataraj G R*, Bharathi D R, Abubaker Siddiq

ABSTRACT

Obesity is a condition in which excess body fat is accumulated to an extent that health may be negatively affected. The prevalence and severity of obesity and its associated co-morbidities are rapidly increasing for the management of obesity ailments. The use of herbal medicines became the subject of interest for the management of obesity due to its natural origin, cost effectiveness and minimal side effects. The present study designed to investigate the effect of Ethanolic extract of Cucumis melo (EECM) 250 and 500mg/kg b.w on energy balance disease like obesity in wistar albino rats using two models namely High fat diet (HFD) and Monosodium glutamate induced (MSG). Obesity was induced by administration of hypercaloric diet for 49 days in HFD model and 15 days in MSG. From the observations of the study, it could be predicted that methanolic extract of Cucumis melo Linn exerted significant antiobesity due to hypophagic. Over the course of study, it was found that Cucumis melo Linn significantly reduced body weight, food intake and lipid profile parameters like LDL, TGs, TC, VLDL, and marked increase in HDL level was observed and significantly decrease SGOT and SGPT levels. In MSG model it showed significant decrease in body weight and food intake no significant changes was observed in water intake. Dose dependent antiobesity activity (250mg/kg, 500mg/kg) was observed with EECM seeds due to presence of phytoconstituents. These results suggest that seeds of Cucumis melo Linn possess Antiobesity activity.