Abstract

*Swadesh Kumar Vishwakarma, Jai Narayan Mishra and Dhaneshwar Kumar Vishwakarma

ABSTRACT

Drug delivery system with gastro-retentive properties is one such proven approach, thereby targeting site specific drug release in the stomach for local or systemic effects. There has been a significant deal of attention in the pharmaceutical sector in developing oral controlled release and site specific drug delivery systems in order to gain greater therapeutic benefit. Drug absorption in the gastrointestinal tract is a highly variable procedure and prolonging gastric retention of the dosage form extends the time for drug absorption. This approach is useful particularly for the drugs which have narrow absorption window in the upper part of gastro intestinal tract. Various approaches of gastro retentive drug delivery system, such as floating and non-floating, have been discussed in this review. This review also gives an overview of merits, demerits and evaluation parameters of gastro retentive system. The development of Gastro retentive drug delivery system has many advantages, such as increasing the bioavailability of the drug, increasing the solubility of less soluble drugs at high pH, controlling the therapeutic rate thereby reducing the incidence of fluctuations, and can extend the half-life thus reducing drug delivery. In this review article we concentrate on some important mechanisms for the delivery of gastro-retentive drugs (floating, bioadhesive, high density, swellable, raft forming, and magnetic systems) in varied dose forms, this drug will be beneficial in the treatment of peptic ulcer.