Abstract

Dr. Shyamal Kanti Das and Dr. Soumendra Nath Karmakar*

ABSTRACT

The objective of the present study was to evaluate the long term toxicity of paracetamol infusion in male albino wister rat. The protective effects of aqueous extract of Tamarindus indica Linn in comparison to Hepamerz were studied on paracetamol induced hepatotoxicity. Different groups of animals were administered with the paracetamol, hepamerz and Tamarind leaf extract for 40 days. Biochemical estimation like SGPT, SGOT, total bilirubin count and serum total protein were done along with hematological study such as total RBC count and Hb%. Also histo-pathological studies of liver tissue were observed. On treatment with paracetamol a significant increase in SGPT, SGOT, total bilirubin, serum total protein and significant decrease in total RBC count, Hb% were observed. Moderate hepato-protective effect as well as significant decrease in the level of SGPT, SGOT and increase in total RBC count was observed after application of the aqueous extract of Tamarindus indica leaf. These results were almost same as hepamerz effect. Histopathological impairment after paracetamol application, was also improved by supplementation of Tamarind leaf extract and hepamerz.