International Journal Of Modern
Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Science & Pharmacy Professional

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2319-5878
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Abstract

INCREASED SEMINAL PLASMA STLR-4 LEVELS IN RELEVANCE TO THE PRESENCE OF BACTERIOSPERMIA AMONG INFERTILE MEN

Emad S. Aboud, Hayder A. L. Mossa* and Haider F. Ghazi

ABSTRACT

Background: Soluble toll like receptor -4 protein level increased due to cellular activation during inflammatory process. Aim: This study aimed toquantitative evaluation of sTLR-4 in seminal plasma of bacteriospermic and none bacteriospermic infertile men. Subjects: A total of 170 semen samples were collected from infertile men attending High Institute for Infertility Diagnosis and Assisted Reproductive Technologies / AL-Nahrain University, Baghdad. Semen samples were processed according to WHO manual 2010 and seminal plasma were used for sTLR-4 measurement using sandwich ELISA kit. Results: The results showed that an elevated sTLR-4 was associated with reduction of grade A motility (r=-0.510) and increased grade D motility (r=0.680), round cell count (r=0.228). Interestingly, it was not related to the leukocyte number (r=0.126). Conclusion: sTLR-4 is sensitive and specific marker for Bacteriospermia in particular pattern of bacterial infection.

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