Abstract

Kamal Kant Ravi, *Kapil Kumar, Gurleen Kaur and Deepak Teotia

ABSTRACT

Rizatriptan Benzoate is potent anti-migraine drug having agonist activity at the 5-hydroxytryptamine (5-HT) 1B & 5-HT 1D receptor. It commonly used for relief of headaches in treatment of migraine. Conventional tablets of RZT are not capable of rapid action, which is required for immediate relief from migraine pain. The aim of present work is to formulate & evaluate floating tablets of Rizatriptan Benzoate prepared by wet granulation methods using effervescent agents like sodium bicarbonate, super disintegrates like HPMC, HPMC K15M and Ethyl Cellulose as diluents & Alcohol was utilized as granulating medium, which increased rate of dissolution may leads to increase in oral bio availability. The prepared tablets were evaluated for uniformity of weight, thickness, friability, content uniformity, hardness, disintegration time, wetting time & for in vitro drug release. Further the tablets were characterized by Fourier transform infrared spectroscopy & differential scanning calorimetry. The correct formulation was subjected to stability at 40±2°C/75±5% RH for 30 days. In-vitro floating studies were carried out which increased the gastric residence time & improved bioavailability of the drug. Rizatriptan Benzoate is potent anti-migraine drug having agonist activity at the 5-hydroxytryptamine (5-HT) 1B & 5-HT 1D receptor. It commonly used for relief of headaches in treatment of migraine. Conventional tablets of RZT are not capable of rapid action, which is required for immediate relief from migraine pain.