Abstract

*Ganesh Prasad Dixit and Hema Jaiswal

ABSTRACT

According W.H.O., Epilepsy is an ongoing non-transferable sickness of the mind that influences individuals, everything being equal. Around 50 million individuals worldwide have epilepsy, making it perhaps the most widely recognized neurological sicknesses internationally. This research focuses on designing and formulation of topical gabapentin hydrogel with different and suitable polymers with different ratio of mixing and evaluation of same by following standard parameters such as physical parameters, pH level, viscosity, % drug release and skin permeation test. In Results, it showed as a transparent and complex hydrogel was formed. The pH was found near to neutral. The viscosity was optimum that confirms for its viscous flow. Skin permeation was found maximum in which permeation agents were incorporated to prepare. In conclusion, it assures that hydrogel of gabapentin exhibited an admirable potential in all the parameters evaluated. This research comes under the New Drug Delivery System (NDDS) that enhances the new approach in frequent dermal delivery of loaded gabapentin hydrogel. It would be very impactful with easier, adequate sustained dosing at desired site with minimal systemic side effects in individual’s sensations of fits and convulsions. Extra investigations are needed to investigate the pharmacokinetic and pharmacodynamic reactions to topically applied gabapentin in additional detail.