Abstract

Kazi Sirin Abrarudin, Shaikh Siraj, Rehan Deshmukh, Qazi Majaz A.* and G. J. Khan

ABSTRACT

The aim of the work is to design Oral pharmaceutical wafer of Ondensetron HCl by using 32 factorial designs. The Total 9 experimental batches (F1…F9) of Ondensetron HCl containing wafers produced following design of experiment and optimized with the help of response surface methodology involving the factors as percentage of polymer and hydrophilic matrix forming, HPMC E 15 as a film forming material, Aspartame as a sweetener and PEG 4000 as a plasticizer. The prepared formulations were subjected for various evaluations such as Appearance, Size and Shape, thickenss, Weight variation, Folding endurance, Percentage moisture loss, Drug content uniformity, Disintegration test, Percent elongation, Surface pH, In-vitro drug release. The study reveals satisfactory results. Hence, the Buccoadhesive Pharmaceutical Wafers Containing Ondensetron HCl is expected to provide clinician with a new choice of safe and more bioavailable formulations.