Abstract

*Kapil Kumar, Gurleen Kaur, Bhawan Singh and Deepak Teotia

ABSTRACT

The purpose of this research was to develop a matrix-type transdermal therapeutic system containing drug propranolol hydrochloride with different ratios of (PVP HPMC) polymeric systems by the solvent evaporation technique by using 30 % w/w of di-butyl phthalate to the polymer weight, incorporated as plasticizer. The physicochemical compatibility of the drug and the polymers studied by infrared spectroscopy suggested absence of any incompatibility. Formulated transdermal films were physically evaluated with regard to thickness, weight variation, drug content, flatness, folding endurance moisture. All prepared formulations indicated good physical stability. In-vitro permeation studies of formulations were performed by using Franz diffusion cells.It shown that drug release follows zero order and the mechanism of release is diffusion from the polymer.