Abstract

Goyal Praveen Kumar*, Singh Gurpreet and Jeyabalan Govindasamy

ABSTRACT

Objective: Leaf of Adiantum incisum (Pteridaceae) has been used in traditional health systems to treat diabetes and many more disorders in southern Asia including India. However hypoglycemic potential of leaf of this valuable plant is not scientifically validated till date. The aim of present study is to evaluate hypoglycemic effect of ethanol extracts of Adiantum incisum leaf. Methods: The ethanol extracts in different dose concentration 100, 200 mg/kg of Adiantum incisum leaf were evaluated for hypo-glycemic potential for 21 days in streptozotocin induced diabetic rats. Results: The outcome of present study indicates, crude extract significantly reduce blood glucose level in diabetic rats. The acute oral toxicity study of A. incisum leaf extract did not show mortality in the animals at the limit dose of 2g/kg. In STZ induced diabetic rat, maximum BGL lowering effect produced by LE2 followed by LE1 after 21 days of treatment. Conclusions: The observed result may be due to active principles present in extract and fractions. The result showed the potential effects of A. incisum leaf extract as hypoglycemic in dose dependant manner compare to glibenclemide as standard drug. The claimed traditional use as anti-diabetic has scientific back ground.