International Journal Of Modern
Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Science & Pharmacy Professional

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2319-5878
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Abstract

IMPACT OF NATURAL DIURETICS IN MANAGEMENT OF EYE-INTRAOCULAR PRESSURE AND HYPERTENSION

Dr. A. M. Krupanidhi*, Prakash Dabadi, Jayamma Kulkarni and Dharithri Joshi

ABSTRACT

The present study was undertaken to focus on extraction of the aerial parts of Dodonaea viscose (DV) subjected to super critical fluid extraction (SCFE) and evaluation of diuretic, eye-intraocular pressure (IOP) and antihypertensive activities on albino Swiss rats using flame photometry and tonometry respectively. The obtained extract was subjected to column Chromatographic separation using silica gel (100-200 and 60-120 mesh).The extracts and isolated fractions were undergone Phytochemical evaluation, acute toxicity study. Further the extracts and fractions were to evaluate diuretic and intraocular pressure (IOP) activities were performed on dexamethasone (2 mg/kg., i.p) induced hypertension in Wister albino rats as per the OECD and CPCSEA guide-lines. The present results revealed that, DV extract and isolated bio compounds showed excellent diuretic activity, decreases rats eye-IOP and ocular antihypertension activities are highly significant.

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