Abstract

Gurleen Kaur, Preeti Budhlakoti, *Kapil Kumar, Deepak Teotia, Ikram

ABSTRACT

Niosomes are a bilayered non-toxic, non-immunogenic nanoparticular delivery system; it is being used for drug delivery. It obtained in the hydration of artificial non-ionic surfactants, without or with addition of cholesterol or additional lipids. The intention of the current study was to organize and evaluate the in-situ niosomal gel loaded with Moxifloxacin for the ophthalmic drug delivery system. Moxifloxacin is in the fluoroquinolone family of medications used to treat a number of bacterial infections. This includes pneumonia and tuberculosis. Moxifloxacin loaded niosomes investigate the connection among the non-ionic drug / surfactant ratio with the adding of cholesterol was successfully organized with the thin film hydration method. Niosomes have been identified by drug entrapment efficiency, drug content, particle size and in-vitro diffusion study. The niosomal in situ gel is a viable alternative to conventional eye drops by virtue of its ability to enhance bioavailability through its longer precorneal residence time and ability to sustain drug release.